Likewise, when Cep55 was constitutively knocked down in TCLs, we found a significant reduction in >4n subpopulations (Fig. 5e, f, Supplementary Fig. 7E), suggesting that Cep55 overexpression contributes to cancer cells ability to tolerate aneuploidy as reported previously by us for breast cancer cells18. The gene discussed is CEP55; the disease is breast carcinoma.