Interestingly, heterozygous Cep55wt/Tg mice developed a lower percentage of adenomas (~20%) and hyperplasia (~8%), suggesting that single copy overexpression of Cep55 is sufficient to initiate tumorigenesis, although the latency significantly differs between Cep55Tg/Tg and Cep55wt/Tg mice. Here, CEP55 is linked to adenoma.