As expected, Alzheimer’s disease-like CBF pattern score was correlated with MoCA in healthy controls (rho =  − 0.669, p = 0.034), suggesting the feasibility of using FDG-PET-based Alzheimer’s disease-like pattern quantification in pCASL-based perfusion imaging. The gene discussed is DOCK3; the disease is early-onset autosomal dominant Alzheimer disease.