COL4A3 and chronic kidney disease: With respect to transcriptome analyses, PDHA1 mRNA levels are significantly decreased during spontaneous kidney disease progression in Col4a3−/− mice51 and mRNA levels are inversely associated with eGFR in patients with diabetic or IgA nephropathy in human CKD (Nephroseq v5, University of Michigan, Ann Arbour, MI, USA).