CCN2 and breast cancer: Reducing CTGF expression transiently reduced invaded area in 3D breast cancer spheroids of mesenchymal transformed breast cancer cells (Fig. 3D and E; MCF-7-EMT 94.25 ± 2.535% vs control; P = 0.032; n = 15) and TNBC cells (Fig. 3D and E; MDA-MB-231 55.93 ± 13.3% vs control; P = 0.0044; n = 9).