CCN2 and breast cancer: Reduced CTGF expression decreased relative proteolytic activity of mesenchymal transformed breast cancer cells (Fig. 4G; MCF-7-EMT CTGF-: 117 ± 28.92% vs. control; P = 0.0205; n = 3), while it did not alter relative proteolytic activity of TNBC cells (Fig. 4G).