Cancer cells, cancer associated fibroblasts, and immune cells modulate ECM by deposition of structural components like collagens or fibronectin (FN1), secretion of growth factors (e.g. Transforming growth factor-beta-induced protein ig-h3, connective tissue growth factor) and ECM-transforming enzymes (e.g. Lysyl oxidase)6. Here, FN1 is linked to cancer.