For instance, the original AML sample from AML-67-001 showed two subclones carrying combinations of DNMT3A-ASXL1-STAG2-BCOR-U2AF1 p.Q84R-U2AF1 p.S34F with NRAS p.G12S or KRAS p.Q61H, that were similar in clonal size. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.