For instance, the original AML sample from AML-67-001 showed two subclones carrying combinations of DNMT3A-ASXL1-STAG2-BCOR-U2AF1 p.Q84R-U2AF1 p.S34F with NRAS p.G12S or KRAS p.Q61H, that were similar in clonal size. This evidence concerns the gene U2AF1 and acute myeloid leukemia.