Transplantation of hiHepPC-derived hepatocytes dissociated from the aggregates and human hepatocytes immediately and significantly ameliorated liver failure, such as increases in aspartate aminotransferase (AST) and alanine transaminase (ALT), at day 2 after transplantation (Fig. 5f), and relatively large amounts of human ALB were detected in the serum of the recipient mice 2 months after transplantation (Fig. 5g). Here, ALB is linked to liver failure.