To determine the expression profile of RPN2 in glioma clinical samples, we first analyzed two TCGA datasets, GBM 29 (containing 154 GBM samples and 5 normal tissues), and GBMLGG14 (containing 5 normal tissues, 516 lower grade, 161 GBM, and 27 recurrent samples), with different histological types. Here, RPN2 is linked to central nervous system cancer.