Most ALS cases are sporadic, and roughly 10% of them are familial forms caused by various genetic mutations in specific genes, including superoxide dismutase 1 (SOD1), transactive response DNA-binding protein-43 (TDP-43), and chromosome 9 open reading frame 72 (C9orf72)5,6. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.