Previous studies reported that, in Alzheimer’s disease, tau phosphorylation was induced by GSK3β, which is activated by PP166,67, and I-2 prevented amyloid-β oligomer (AβO)-induced defects in brain-derived neurotrophic factor (BDNF)-containing vesicle transport67. This evidence concerns the gene GSK3B and early-onset autosomal dominant Alzheimer disease.