Recently, it was reported that the expression of Drp1 was induced in the spinal cord of SOD1 G93A model mice31, and the suppression of Drp1 inhibited mutant SOD1-induced mitochondrial fragmentation and cell death in vitro2, suggesting that alteration of Drp1 activity may mediate at least some aspects of MN degeneration in ALS. The gene discussed is DNM1L; the disease is amyotrophic lateral sclerosis.