Recently, it was reported that the expression of Drp1 was induced in the spinal cord of SOD1 G93A model mice31, and the suppression of Drp1 inhibited mutant SOD1-induced mitochondrial fragmentation and cell death in vitro2, suggesting that alteration of Drp1 activity may mediate at least some aspects of MN degeneration in ALS. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.