When evaluated as a tool for the diagnosis of TBM in children, a modified version of an adult serum seven-marker signature (C-reactive protein [CRP], IFN-γ, IP-10, CFH, Apo-A1, SAA, and NCAM) diagnosed TBM with moderate accuracy (sensitivity of 73.9% and specificity of 66.7%) (90). The gene discussed is APOA1; the disease is meningeal tuberculosis.