Importantly, the frequent alterations of genes that encode epigenetic factors, such as the SWI/SNF complex genes PBRM1 and ARID1A, in addition to KDM6A, BAP1 and FBXW7 indicate that dysregulation of chromatin remodeling is a common feature across all higher-grade meningiomas, regardless of the molecular subgroup [2, 20, 24, 33, 34, 39]. The gene discussed is BAP1; the disease is meningioma.