Taking into account that KDM6A, which is located on chromosome X and escapes X-inactivation, acts antagonistically to PRC2 and promotes H3K27 demethylation, our findings may partly explain the upregulated PRC2 activity in the NF2-mutant group of meningiomas after inactivation of KDM6A [10, 24, 38, 39]. This evidence concerns the gene NF2 and meningioma.