Similarly, KDM6A alterations occurred significantly more often in WHO grade 3 meningiomas (n = 15/176, 9%) versus 13/441 (2.9%, p = 0.0046) and 2/220 (0.9%, p = 0.0001) in WHO grade 2 and 1 meningiomas, respectively. Here, KDM6A is linked to meningioma.