Interestingly, we did not detect frequent clinically targetable gene rearrangements in any of the subclasses in our study, indicating that progressive/high-grade meningiomas are seldom driven by gene rearrangements that are characterized in our genomic assay and are ineligible for targeted therapeutic agents against fusion oncogenes (e.g., NTRK, ALK, etc.). This evidence concerns the gene ALK and meningioma.