TP53 mutations occurred mainly in WHO grade 3 meningiomas (n = 12/176, 6.8%) followed by WHO grade 2 (n = 10/441, 2.2%, p = 0.0135) and a significantly lower percentage in grade 1 (n = 2/220, 0.9%, p = 0.0018) meningiomas. The gene discussed is TP53; the disease is meningioma.