As seen in Fig. 5, we found that Galu could suppress Iκκβ/NF-κB signaling pathway through downregulating Iκκβ, p-NF-κB p65, and p-IκB expression, which were upregulated by si-HO-1 plasmid in the RA-FLS cells. This evidence concerns the gene IKBKB and rheumatoid arthritis.