Moreover, UBE2T overexpression led to an increase in the percentage of cells with > 10 RNF8 foci, and the knockdown of UBE2T decreased RNF8 foci formation in the nuclei of HCC cells after IR, indicating that UBE2T facilitates RNF8 accumulation around DSB sites in response to IR (Fig. 7e-f). The gene discussed is RNF8; the disease is hepatocellular carcinoma.