BRCA1 and breast cancer: For instance, bilateral mastectomy is offered to individuals with pathogenic variants found in BRCA1 (which is associated with 73% increased risk of developing BC by age 80) as well as to individuals with pathogenic variants found in PALB2 (which is associated with a 50% increased risk of developing BC by age 80) – the latter is detected by the panel but not by standard BRCA1/2 testing [15].