The subgroup analysis according to East Asian (20 articles) and non-East Asian (35 articles) title revealed the significant association between IL4 gene -589C/T polymorphism and the risk of asthma across in all genotype models of East Asians and three genotype models of non-East Asian including; recessive model (OR = 1.25, 95% CI = 1.08–1.45, P < 0.001, FEM), allelic model (OR = 1.15, 95% CI = 1–1.32, P = 0.04, REM), TT vs. CC model (OR = 1.34, 95% CI = 1.12–1.61, P < 0.001, FEM) (Table 3, Fig. 4). This evidence concerns the gene IL4 and asthma.