IL4 and asthma: Moreover, in contrast with effect of IL4 gene -589C/T SNP on the risk of asthma in American populations, a significant positive association was detected in European population thorough dominant model (OR = 1.46, 95% CI = 1.15–1.85, P < 0.001, REM), allelic model (OR = 1.34, 95% CI = 1.12–1.61, P < 0.001, REM), TT vs. CC model (OR = 1.53, 95% CI = 1.10–2.14, P = 0.01, FEM), and CT vs.CC model (OR = 1.44, 95% CI = 1.13–1.83, P < 0.001, REM) (Table 3, Fig. 3).