For SLC2A9, rs6855911, rs6449213 and rs7442295 could significantly lower risk of gout (OR1 of 0.35–0.38 and OR2 of 0.65–0.69) and serum urate (MD1 of − 54.30 to − 49.29 and MD2 of − 20 .65 to − 18.34) in Caucasians. This evidence concerns the gene SLC2A9 and gout.