ABCG2 and gout: The effect of rs72552713 on increasing the risk of gout is supported by the fact that it is a nonsense variant causing a stop codon that prematurely ends protein translation of ABCG2; Matsuo et al. [42] also reported the absence of ABCG2 protein expression and the almost entirely removed urate transport activity due to rs72552713 in the functional analysis.