After excluding one Caucasian study in type 2 diabetes (T2D) patients, sub-group analysis yielded stronger effects of these SNPs in a general population with pooled MD1 and MD2 of − 40.16 (− 47.74, − 32.57) and − 15.80 (− 23.36, − 8.24) for rs1014290; and − 55.67 (− 82.77, − 28.57)) and − 29.00 (− 41.82, − 16.19) for rs734553. Here, LY96 is linked to type 2 diabetes mellitus.