KDR and neoplasm: In their study, activated vascular endothelial growth factor receptor 2 (VEGFR2) signaling within tumor endothelial cells upregulated the transcriptional repressor, positive regulatory domain I–binding factor 1 (PRD-BF1), which suppresses genes involved in type I interferon-mediated anti-viral activity, thereby making tumor vessels sensitive to OV infection [30].