PALB2 and breast carcinoma: Yang et al. also showed that protein truncating variants in PALB2 were associated with increased risk of female and male breast cancer (RR 7.18 95% CI 5.8–8.8 and 7.34 95% CI 1.2–42.8, respectively) and pancreatic cancer (RR 2.37 95% CI 1.2–4.5) [12].