BRCA1 and ovarian cancer: Due to the magnitude of ovarian cancer risk associated with variants in BRCA1 and BRCA2, risk-reducing salpingo-oophorectomy (RRSO) is currently recommended as a prevention strategy for BRCA1 carriers by age 35 to 40 years, once the woman’s childbearing is complete, and for BRCA2 carriers by age 40 to 45 [39].