In a large prospective study of BRCA carriers ascertained through family clinics, the cumulative risk, by age 80, of ovarian cancer in women with pathogenic variants in BRCA1 and BRCA2 was estimated to be 44% (95% confidence interval (CI), 36–53%) and 17% (95% CI, 11–25%), respectively [9]. Here, BRCA1 is linked to ovarian carcinoma.