Autocrine production of IL-8 is inversely associated with cancer cell responses to tamoxifen, and tamoxifen-resistant derivative cells exhibit elevated IL-8 expression, thereby suggesting that IL-8 could also be a cause and indicator of endocrine resistance as a part of the IL-8-mediated program of metastatic progression of breast cancer [19,20,21,22,23,24,25,26]. The gene discussed is CXCL8; the disease is cancer.