HSP20 is an important member of the HSP family and is present in cardiomyocyte-derived circulating exosomes, promoting the formation of myocardial neovascularization and blocking tissue necrosis factor α (TNF-α) and interleukin 1β (IL-1β) to reduce the risk of MI [151]. Here, HSPB6 is linked to myocardial infarction.