Notably, HLA-A3 and HLA-B8 are underrepresented in BCR-ABL+ CML [3], and HLA-B*07, B*18, and B*40 protect against NPM1-mutant AML [4], Furthermore, HDs also have memory T cells specific to aberrantly phosphorylated antigens [39], and the newly identified HD T memory responses specific to CALR exon 9 mutations [13] add further impetus to the notion of the elimination of transformed cells in HDs by neo-antigen-specific T cells. This evidence concerns the gene NPM1 and chronic myelogenous leukemia, BCR-ABL1 positive.