CD4 and neoplasm: To gain more insight into the possible contribution of T cell-mediated antitumor immunity to Doxil®-mediated tumor growth suppression in the immunocompetent mice, levels of both CD8+ and CD4+ T cells in tumor tissue of immunocompetent mice was determined following treatment with either free DXR or Doxil® (Figure 1D, Supplementary Figure S1).