Tumor growth is suppressed in a xenograft Nur77/Nurr1-double knockout mouse model and the expression of Treg-signature genes, including Foxp3 and CTLA-4, is attenuated, without development of autoimmunity, but Nur77- or Nurr1-single knockout mice are not able to delay or inhibit tumor growth [82]. Here, NR4A2 is linked to neoplasm.