In addition, reduction in the gene dosage of Nur77 and NOR-1 in hypoallelic (Nur77+/−NOR-1−/− or Nur77−/−NOR-1+/−) mice beyond a critical threshold is also sufficient to cause a mixed myelodysplastic/myeloproliferative disease with progression to acute myeloid leukemia [36]. The gene discussed is NR4A1; the disease is acute myeloid leukemia.