In addition, reduction in the gene dosage of Nur77 and NOR-1 in hypoallelic (Nur77+/−NOR-1−/− or Nur77−/−NOR-1+/−) mice beyond a critical threshold is also sufficient to cause a mixed myelodysplastic/myeloproliferative disease with progression to acute myeloid leukemia [36]. Here, NR4A1 is linked to myeloproliferative disorder.