CD11b-expressing cells are definitely more present in the PKI;POU2F3+/+ tumors since we clearly see the infiltration among the stroma as foci at the edge of the high grade PanIN (Figure 4) as observed in the PKI;POU2F3+/+ pancreatic tumors (Figure 2A). This evidence concerns the gene POU2F3 and pancreatic neoplasm.