High CD73 mRNA expression was significantly associated with extrathyroidal extension (p < 0.001), advanced pathologic (p) T category (p = 0.004), lymph node metastasis (p < 0.001), distant metastasis (p = 0.025), advanced American Joint Committee on Cancer (AJCC, 7th edition) stage (p = 0.002), BRAF-like molecular signature (p < 0.001), and increased American Thyroid Association (ATA) recurrence risk (p < 0.001). This evidence concerns the gene NT5E and metastatic malignant neoplasm in the lymph nodes.