PLAT and skin neoplasm: Additionally, bergenin and gallic acid, isolated from P. pterocarpum, exhibited potent inhibitory effects against EBV-early antigen activation and skin tumor promotion in an in vivo, two-stage, mouse skin carcinogenesis test, using 7,12-dimethylbenz[a]anthracene as an initiator and tissue plasminogen activator (TPA) as a promoter [13].