Using K14-driven, skin-specific PLA2G2A-transgenic mice, Chovatiya et al. [28] recently demonstrated that sPLA2-IIA promotes hair follicle stem cell proliferation through JNK signaling and that sPLA2-IIA-knockdown skin cancers xenografted into NOD-SCID mice show a concomitant reduction of tumor volume and decreased JNK signaling. This evidence concerns the gene MAPK8 and neoplasm.