PLA2G10 and colitis: Accordingly, Pla2g10−/− mice display more severe epithelial damage and inflammation with reduction of colonic ω3 PUFAs rather than ω6 AA in a colitis model, while PLA2G10-transgenic mice exhibit global anti-inflammatory phenotypes in association with elevation of systemic levels of ω3 PUFAs and their metabolites [33].