PLA2G3 and malignant colon neoplasm: For instance, sPLA2-III-transfected colon cancer cells xenografted into nude mice show increased growth [47], higher expression of sPLA2-III in human colorectal cancer is positively correlated with a higher rate of lymph node metastasis and shorter survival [48], and polymorphisms in the human PLA2G3 gene are significantly associated with a higher risk of colorectal cancer [49].