Furthermore, Pla2g3−/− mice are less susceptible to colitis, with lower expression of pro-inflammatory and pathogenic Th17 cytokines and higher expression of epithelial barrier genes [50], implying that amelioration of colonic inflammation by sPLA2-III ablation underlies the protective effect against colon cancer. This evidence concerns the gene PLA2G3 and malignant colon neoplasm.