Similarly, while one may suggest that there is no difference in age and sex between TMD and ALS, these are two very different diseases, with TMD being a late-onset, autosomal dominant distal myopathy, resulting from mutations in the two last domains of titin (associated with the unfolded protein response and altered autophagy) and with ALS being essentially a sporadic disease associated with several genetic deficits (Table S1). The gene discussed is TTN; the disease is amyotrophic lateral sclerosis.