These findings suggest a cross-regulation of ADNP and PACAP functions, with the PAC1 receptor antagonist, PACAP(6–38), reducing urinary bladder frequency and pelvic sensitivity in mice exposed to repeated variate stress [48] and with the majority of ADNP syndrome patients suffering from bladder training delay [5]. This evidence concerns the gene ADCYAP1 and ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder.