In contrast, the increase of ADNP in BMD and ALS was coupled to an increase in MAPRE1, while DYSF- and FKRP-related diseases did not show a significant change in MAPRE1. These results suggested differential regulation of ADNP/MAPRE1 in the different muscle diseases, with MAPRE1 consistently increasing (or showing no significant change) and with ADNP auto-regulating its own transcript levels [9,76] in a feedback mechanism. This evidence concerns the gene MAPRE1 and amyotrophic lateral sclerosis.