ACTA1 and amyotrophic lateral sclerosis: STRING analysis for functional interactions included the mutated muscle disease-causing proteins (Figure 6B) alpha-actin (ACTA1), a major cytoskeletal gene, MAP1LC3B, a protein regulating autophagy, directly binding ADNP [13,27] and for ALS, C9orf72, a gene also linked to autophagy [68] and interacting with CNBP (causing DM2).