ADNP and ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder: Given our results correlating between ADNP expression and human muscle aging and our current transcriptomic analyses at the single human muscle cell level indicating a potentially crucial role for ADNP in muscle development, as exemplified in the ADNP syndrome [5,7,8,71], we investigated the involvement of ADNP in several NMJ pathologies (some highly prevalent in males) and discovered significant dysregulation.