Williams–Beuren syndrome (WBS) is a rare developmental disorder (1:10,000) with multisystemic manifestations caused by segmental aneusomy of 1.55–1.83 Mb at chromosomal band 7q11.23, which includes ELN and 25–27 additional genes (Williams–Beuren syndrome critical region, WBSCR). Here, ELN is linked to Williams syndrome.