Furthermore, bFGF alone might induce an inflammatory response and osteophyte formation without significant repair when injected into an osteochondral defect at the medial femoral condyle in rabbits [56], Meanwhile, the intraarticular injections of GM-incorporated bFGF drastically suppressed the progression of osteoarthritis (OA) [43]. The gene discussed is FGF2; the disease is osteoarthritis.