IFNA1 and chronic myelogenous leukemia, BCR-ABL1 positive: In particular, the treatment of CML monocytes with IFN-α and GM-CSF allowed the rapid generation of activated IFN-DC expressing IL-15, which induced IFN-γ production by cocultured autologous T lymphocytes and stimulated the expansion of CD8+ T cells, which were reactive against autologous leukemic cells [60].