While IFN-α has been reported to induce a graft-versus-leukemia effect (GVL) when administered with donor leukocyte infusion (DLI) in patients who relapsed after allogeneic transplantation [59], the combination of IFN-α with GM-CSF can effectively drive the differentiation of monocytes from leukemic patients into DC-like-cells promoting anti-leukemic cytotoxicity [60,61,62]. Here, IFNA1 is linked to leukemia.