The silencing of Runx-2 down-regulates EMT-related molecules (snail family transcriptional repressor (SNAI)2, SNAI3, and twist-related protein 1 (TWIST1)), MMP2, and vasculogenic factors (VEGFA and VEGFC) in thyroid carcinoma cells, and suppresses thyroid carcinoma cell invasion in transwell assays [98]. The gene discussed is VEGFC; the disease is thyroid gland carcinoma.