TNF and psoriasis: However, in contrast, IL-4 and IL-10 decreased significantly, in line with their anti-inflammatory properties; indeed IL4 inhibits the macrophage production of the IFN-γ, TNF-α, and IL-1-related pathways [55] and has been successfully used in the treatment of psoriasis [56]; IL-10 inhibits MHC class II and co-stimulatory molecule B7-1/B7-2 expression on monocytes and macrophages [57], reducing inflammation.