GW6471 combined with PD-L1 blockade strongly increased the number of tumor antigen-specific CD8+ T effector cells (OT I tetramer+) (Figure 6L) and highly boosted the production of granzyme B (GrmB), perforin, and IFN-γ from CD8+ T cells (Figure 6M). Here, PRF1 is linked to neoplasm.