Additionally, the finding that HPV still undergoes disassembly in cells depleted of p120 (or γ-secretase) but not in cells in which endosome acidification is blocked indicate that p120 and γ-secretase do not promote initial endosome entry of HPV, despite the fact that p120 binds to HPV at early timepoints during infection. This evidence concerns the gene CTNND1 and infection.