EGR1 and gestational diabetes: A study revealed that AGE-mediated activation of early growth response protein 1 (EGR-1) and its downstream factors via protein kinase C- βII (PKC-βII) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway (AGEs/PKC-βII/ ERK1/2/EGR-1 pathway), is a novel mechanism of inducing vascular inflammation in GDM [57].