Future perspectives of the current model may also be focused on isolating tumor-derived endothelial cells, which anti-apoptotic features are sustained by VEGF-D, as described by Bussolati and colleagues [51], and obtaining knock-out cells for intravasation-related genes (e.g. VEGFR-3) to re-inoculate in SCID mice. The gene discussed is VEGFD; the disease is neoplasm.