At last, H&E histological findings combined with the assessment of cell proliferation by Ki-67, and the immunohistochemical characterization of nuclear transcription factors, E-cadherin, and F-actin were suggestive of an invasive behavior of the HEK-EBNA293-VEGF-D cells most likely due to EMT-like processes in the TCi at the periphery of the tumor. The gene discussed is MKI67; the disease is neoplasm.