VEGFA and neoplasm: Studies in zebrafish models [7] and with the MDA- MB-231 mammary tumor cells (M.D. Anderson—metastasis breast cancer) indicate that vascular endothelial growth factor (VEGF) prompts an increase of tumor cell permeation by activation of Ca2+-dependent signals thought to induce endothelial cell retraction and actin redistribution [8, 9].