CDH1 and neoplasm: On the other hand, the cytoplasmic and membranous protein expression analysis showed that both in tumor periphery (mean score = 0.20) and within the center (mean score = 0.22) there was a low number of E-cadherin immunolabeled cells with a weak cytoplasmic to membranous staining, without significant difference (p = 0.8297; Fig 2F1–2F5).