Moreover, the high proliferation activity provided by Ki-67 expression together with the increased number of immunolabeled cells for the analyzed transcription factors (pAKT, pERK, ZEB, TWIST) at the tumor invasive front, further support the invasive behavior of the HEK-EBNA293-VEGF-D cell line in the present xenograft model. Here, MKI67 is linked to neoplasm.