As shown in Supplementary Figure 3A and Supplementary Table 2, a total of 18 genes were significantly negatively correlated with DGCR5, including GNAI3 [30], VIM [31], ITGB1 [32, 33], HIF1A [34], and HDAC1 [35], all of which are critical factors affecting glioma development. Here, HIF1A is linked to central nervous system cancer.