SNCA and Parkinson disease: We observed increased expression of BAG5 in tyrosine hydroxylase (TH)-positive nigral neurons of transgenic SNCA p.A53T PD mice, which express a p.A53T missense mutant form of the human α-synuclein (SNCA) gene under the control of the murine prion promoter (Figure 7A), compared to that in littermate wild-type mice.