For example, the poly(ADP‐ribose) polymerase 1 (PARP1) physically interacts with the β‐catenin/TCF7L2 module and functionally potentiates its transcriptional activity in CRC likely via PARylarion (Idogawa et al., 2005), or the transducin β‐like protein 1 (TBL1), which seems to recruit β‐catenin to Wnt target‐gene promoters for transcriptional activation during oncogenesis (Li & Wang, 2008). The gene discussed is TCF7L2; the disease is colorectal carcinoma.