APC and colorectal carcinoma: While APC mutations are present in ca. 80% of CRC, mutations in AXIN is most prevalent in hepatocellular carcinomas, while activating mutations in CTNNB1 have been found with high frequency in melanoma and thyroid tumors (Groden et al., 1991; Kahn, 2014; Mazzoni & Fearon, 2014; Powell et al., 1992).