This supports the hypothesis that, in CRC cells, BCL9/9L enhances Wnt target gene transcription to the “just‐right” amount that allows carcinogenesis (Albuquerque et al., 2002; Gay et al., 2019) and their loss offers a perfect therapeutic window, for it causes the downregulation of gene expression just below a crucial threshold that impairs aggressive cancer behavior and regeneration but not normal homeostasis (Deka et al., 2010; Gay et al., 2019). This evidence concerns the gene BCL9 and colorectal carcinoma.