For example, in the absence of TCF/LEF, β‐catenin sticks to FOXO TFs to activate a so‐called GHOST response (Doumpas et al., 2019), which includes the transcription of genes such as Matrix metalloproteases (MMP13) whose overexpression is a prognostic marker for CRC (Huang et al., 2010). This evidence concerns the gene HNF4A and colorectal carcinoma.