Intriguingly however, deletion of Bcl9/9l prolonged lifespan of mice carrying the Apc1322T mutation (which encodes a truncated but partially‐functional APC commonly found in CRC) significantly more than Pygo1/2 genetic recombination (Mieszczanek et al., 2019), and PYGO1/2 also seem to be not particularly relevant in chemically induced colorectal carcinogenesis (Zimmerli et al., 2020). This evidence concerns the gene BCL9 and colorectal carcinoma.