TET2 directly binds to the mRNA 3′-UTR of Socs3, a negative regulator of JAK-STAT pathway which is important for cytokine-induced myelopoiesis during pathogen infection, and decreases the 5mC level in this region in an enzymatic activity-dependent manner, therefore promoting the degradation of Socs3 mRNA through ADAR1 and activating the emergency production of mature innate immune cells during pathogen infection (Shen et al., 2018). The gene discussed is SOCS3; the disease is infection.