TET2 and type 1 diabetes mellitus: Expression of IFN-α in pancreatic islets during acute or chronic infections, post-transcriptionally increases expression of TET2 through targeting miR-26a for degradation, which in turn increases global 5hmC level of pancreatic β cells, resulting in the initiation of islet autoimmunity in T1D (Stefan-Lifshitz et al., 2019).