TET2 and infection: TET2 directly binds to the mRNA 3′-UTR of Socs3, a negative regulator of JAK-STAT pathway which is important for cytokine-induced myelopoiesis during pathogen infection, and decreases the 5mC level in this region in an enzymatic activity-dependent manner, therefore promoting the degradation of Socs3 mRNA through ADAR1 and activating the emergency production of mature innate immune cells during pathogen infection (Shen et al., 2018).