LPL and atherosclerosis: Additionally, coiled-coil domain-containing 80 (CCDC80) inhibits the phosphorylation of ERK1/2 and decreases the expression of TET2, which upregulates the methylation level of lipoprotein lipase (LPL) promoter region, and impairs the interaction of TET2 with the transcription factor FOXO3a, causing a reduction of LPL expression and finally the acceleration of atherosclerosis (Gong et al., 2019).