In addition, we show that in advanced squamous cervical lesions (CIN2I and CIN3/CIS), megalin expression rises also on several lymphoid, epithelial and endothelial cells, as well as that numerous stromal, macrophage-like cells, expresses MT-I/II immunoreactivity, indicating that these changes may participate in a reprogramming and polarization of the innate cell compartment and contribute to immune system inhibition and tumour progression and dissemination. The gene discussed is LRP2; the disease is neoplasm.