In agreement with a number of previous reports, pointing to high MT expression in uterine cervical squamous lesions and in aggressive endometrial adenocarcinomas [24–26, 31], in the current study, we have confirmed that MT-I/II overexpression may be found within the transformation zone of the cervix particularly in the cases of HSILs (CIN2 and CIN3/CIS). This evidence concerns the gene MCAT and endometrium adenocarcinoma.