LRP2 and in situ carcinoma: In an attempt to enlarge still limited data available on the role of MTs in uterine cervical squamous lesions [24–26], in the present study, we made immunohistochemical profiling of MT-I/II and megalin expression in different types of pre-invasive intraepithelial neoplasia-LSIL(CIN1) and HSIL (formerly subdivided into CIN2 and CIN3/carcinoma in situ) that in some cases progress to invasive cervical cancer, which represents the fourth leading cause of cancer-related deaths in women worldwide [27].