IARS1 and in situ carcinoma: Moreover, in HSILs increased the nuclear expression of MTs (high IRS was found in 80% of CIN2 and in 53.3% of CIN3/CIS cases) and the infiltration with MT-I/II positive MNLC (high IRS were found in 66.7% and 73.3% of cases, respectively) (Fig. 1C; Table 2 supplement).