Some of the latest findings have shown that TIM3 acts as a biomarker that represses the spontaneous immune reactions in the high grade serous ovarian cancers (HGSC) [8], and up-regulation of TIM3 and regulatory T-cell infiltration could mediate the resistance to radiation therapy and PD-L1 blockade [9]. This evidence concerns the gene HAVCR2 and ovarian serous adenocarcinoma.