Indeed, diabetes development is accelerated by some TCRs, such as the CD4+ TCRs BDC-6.9 [36] (recognising a proinsulin/islet amyloid polypeptide hybrid peptide [37]) and 4.1 of unknown specificity [38] and the CD8+ islet-specific glucose-6-phosphatase catalytic-subunit related protein (IGRP)206–214-reactive 8.3 TCR [38]). Here, INS is linked to diabetes mellitus.