Others do not accelerate diabetes development (i.e. the CD4+ TCR BDC-2.5 reactive to a proinsulin/chromogranin-A hybrid peptide [37]), unless on a NOD/scid immunodeficient background [39], and the CD8+ InsB15-23-reactive G9C8 TCR, which requires prior InsB15-23 immunisation [40]). This evidence concerns the gene CD4 and diabetes mellitus.