ARHGEF12 and coronary artery disorder: Moreover, 7 CR genes that are LoF intolerant (probability of LoF intolerance by the Genome Aggregation Database, >0.50) and highly expressed in the developing heart had LoF variants in 3 or more patients with unexplained CHD (rho guanine nucleotide exchange factor 12 [ARHGEF12], CTNNB1, lipoma-preferred partner [LPP], afadin [MLLT4], phosphatase and tensin homolog [PTEN], TCF12, and transferrin receptor [TFRC] genes; Table 2).