Someevidence suggests negative long-term effects of anti-VEGF therapy on the ganglioncell complex (GCC) with a significant decrease in the ganglion cell layer (GCL)compared with that in untreated eyes after long-term anti-VEGF therapy in patientswith age-related macular degeneration (AMD)(10). The gene discussed is VEGFA; the disease is age-related macular degeneration.