Among the stage IV adenocarcinoma patients tested for EGFRms (n=129), EGFR-TKIs were prescribed as a first-line treatment in 14 cases; 27 (out of 31) patients with stage IV adenocarcinoma and positive EGFR mutations received an EGFR-TKI treatment (data not shown). The gene discussed is EGFR; the disease is adenocarcinoma.