PNPLA2 and cancer: In spite of the up‐regulation of PTGDS and ADORA1, genes for (i) the key lipases ATGL and HSL,8 (ii) PLIN1, which is required for activation of lipolysis,13 (iii) cell death‐inducing DNA fragmentation factor (CIDEA), which counteracts inhibition of lipolysis by AMP‐activated protein kinase,9 and (iv) zinc‐α2‐glycoprotein, the lipolytic factor known to be induced in cancer cachexia,26 tended to be up‐regulated in cachectic patients (Figure1A).