However, gene set enrichment analysis (GSEA) of hallmark genes identified multiple pathways that were significantly (P < 0.05) downregulated by RUNX1T1 overexpression in NSCLC cell lines (H1650, H1299) or upregulated by RUNX1T1 knockout in SCLC cell lines (H82, H2171) (shown in Fig. 3C, see Figures S2 and S3 for details). The gene discussed is RUNX1T1; the disease is small cell lung carcinoma.