Furthermore, the in vivo antitumoral activity of 16A‐MMAE was assessed using a syngeneic tumor model in hMUC1‐Tg mice using a B16‐OVA cell line stably transfected with human MUC1. The results indicate that 16A‐MMAE inhibits tumor growth in mice in a dose‐dependent manner (Figure S9). The gene discussed is MUC1; the disease is neoplasm.