In fact, Dakson and collaborators, by analyzing the content of Pin1 in hippocampal and cortical neurons of brains from AD patients, demonstrated an increase in Pin1 immunoreactive granules within the hippocampal regions of CA2, CA1, subiculum, and presubiculum, whereas minimal occurrence or complete absence have been reported in cortical areas with prominent NFT pathology, such as the entorhinal and temporal cortices [43]. The gene discussed is PIN1; the disease is Alzheimer disease.