Intriguingly, a similar redistribution and reduction of Pin1 have been observed in a range of frontotemporal dementias (FTDs), both with tau pathology (FTD with tau mutation, Pick disease, corticobasal degeneration) and without tau pathology (frontotemporal lobar degeneration with motor neuron-type inclusions, and neuronal intermediate filament inclusion disease) [16]. Here, PIN1 is linked to frontotemporal dementia.