PIN1 and Alzheimer disease: As an example, a study by Segat et al. identified two single nucleotide polymorphisms at positions − 842 and − 667 in the promoter region of PIN1 gene and reported a significantly higher percentage of − 842C allele carriers in AD subjects compared to controls, suggesting that the inheritance of such allele may alter Pin1 expression and, consequently, enhance the risk of developing AD [48].