Notably, Iridoy et al. recently analyzed the pattern of Pin1 expression by using a proteomic approach, demonstrating a trend for downregulation of Pin1 in human non-motor cortex and in the spinal cord derived from patients with ubiquitin frontotemporal lobar degeneration (FTLD-U), the most common form of FTD [17]. The gene discussed is PIN1; the disease is frontotemporal dementia.