In this regard, Ferri et al. reported a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter in FTD subjects, while a higher Pin1 gene expression with a lower DNA methylation in late-onset AD patients and controls, corroborating the hypothesis of a diverse involvement of Pin1 in different types of dementia [63]. Here, PIN1 is linked to Alzheimer disease.